Wednesday, January 29, 2020
Transformational leadership on World health care Essay Example for Free
Transformational leadership on World health care Essay Introduction            Transformational leadership can be defined and utilized based on specific or relative circumstances in many varied ways. For one, it can be assessed as the task of simply increasing the efficiency of everyone through a scheme of excellence for the whole company or the improvement of the morale of an individual employee. The main assumption behind this approach is that when employees of a certain company or organization are working their tasks efficiently, the amount and quality of work done are proportionally affected. In essence, employees that are more efficient translate into far greater options and larger benefits. The correlation is thus an important aspect in the leadership skills of the heads of various companies and organizations.            For the most part, transformational leadership can be used as a tool not only in analyzing the crucial aspects of world health care but also in directly addressing the cases that shape the totality of the events related to the broad scope of global health care. The complexities involved in the cross-continental management and maintenance of the multitude of interrelated functions.            The task of meeting the multiple health care services across the different parts of the world that direly need immediate action calls forth an approach whereby the functioning of the wide number of health care service providers are efficiently met. Transformational leadership, following its basic principle, offers means in which the tasks required in addressing world health care are met. Noting further that transformational leadership aptly disperses the capabilities of the employees and, consequently, the different departments or institutions that comprise the whole of the company, the application of this approach on the various issues that are involved in the global arena of health care may eventually help alleviate the global challenge attached to world health care. A look into transformational leadership            Transformational leadership, in essence, signifies the role of the â€Å"leader†in directing the rest of his or her subordinates in a fitting manner that will bring about favorable results to the functioning of every employee, department, and of the whole company in the process. However, the apparent effect of the role of the leader on the subordinates in the company can be further observed and analyzed from a closer examination on what makes a leader able to affect his subordinates apart from the boss-subordinate relationship (Antonakis House, 2001).            One aspect that separates transformational leadership a cut above the rest is that it defines the extent to which a leader is seen as charismatic to his subordinates. The core principle behind this is that leaders should treat their subordinates or employees as individuals who are also capable of thinking for themselves, or individuals who are intellectually stimulating (Tichy Devanna, 2001).            By treating the lower â€Å"ranks†or departments of the company as entities capable of actually affecting the intellectual direction of the company, the employees will not merely serve as passive elements in the upbringing of the company but as active elements capable of pouring into that intellectual basin their knowledge on the affairs of the company.            The result will be that the efforts of the leader in guiding the direction of the company will be amplified since the employees are treated in a manner in which they are involved in the critical processes. Moreover, a good leader will bring about a heightened sense of life into the company. The role of transformational leadership in world health care            World health care has been a primary concern among the international community for the past few years. Many factors are attributed to the growing concern over the issues that are directly related to the problems that beset world health care.            Among the various countries that are in deep need of health care, those that belong to the third-world countries are most notable. Inasmuch as these countries lack the internal capacity to finance and support a growing demand for health care, these nations also have a relatively low means in achieving at least good health for a small fraction of the population. A very limited number of infrastructures and programs that are aimed at addressing the health care issues of these nations amplify the drastic situation even more.            This is the point wherein the international community has resorted to measures that will seek to address the current health issues that beset the citizens of countries suffering from low-health maintenance. For the most part, the international community has joined efforts in seeking out the best possible means in resolving these global health issues. The consequent effect to this is the creation of various international institutions that operate on the local levels of various countries.            Since the operations of these global institutions are tilted on a multitude of local areas, it is apparent that a number of workers are seen to be handling these local operations. In this light, the role of a transitional leadership is needed to take its shape.            By having a transitional leadership in the management of all the affairs taken by the various institutions, the possibility of having a full line of efficient institutions can take place. That is, by treating all the employees who will handle the tasks relative to the specific institutions in these international health offices as individuals capable of contributing to the think-tank process, the process will be further stimulated. These individuals, as partakers in the critical thinking process, are further empowered and acquire a higher role in the global effort of resolving world health care issues.            On the local level, these working individuals can be further guided according to the tasks by relegating a leader whose charisma gives positive effects to the working attitude and philosophy of the employees. Thus, the implementation of health policies from these various international institutions becomes an easy and efficient task in the case where employees have little or no defiance to the implementation of the tasks. Conclusion Far more importantly, transitional leadership allows the development of the employees in terms of their personal growth and in their working attitude. It contributes the international efforts in resolving the issues that beset world health care inasmuch as the international community operates on the local level or in the localities with poor health conditions, especially in communities belonging to the third-world countries. References Antonakis, J., House, R. J. (2001). Transformational Leadership. In B. J. Avolio F. Yammarino (Eds.), Transformational and Charismatic Leadership (pp. 3-66): JAI Press. Bhargava, S. (2003). Transformational Leadership: Value Based Management for Indian Organizations: Sage Publications Pvt. Ltd. Ginter, P. M., Duncan, W. J., Sappington, A. A., Swayne, L. E. (2005). Strategic Management of Health Care Organizations (5 ed.): Blackwell Publishing Incorporated. Porter, M. E., Teisberg, E. O. (2006). Redefining Health Care: Creating Value-Based Competition on Results (1 ed.): Harvard Business School Press. Tichy, N. M., Devanna, M. A. (2001). The Themes, The Protagonists, The Transformational Drama. In Transformational Leader (2 ed., pp. 8): Wiley.
Tuesday, January 21, 2020
The Evil of Richard the Third :: essays research papers
The Evil of Richard III Shakespeare Richard III was a traitor, a murderer, a tyrant, and a hypocrite. The leading characteristics of his mind are scorn, sarcasm, and an overwhelming contempt. It appears that the contempt for his victims rather than active hatred or cruelty was the motive for murdering them. Upon meeting him he sounds the keynote to his whole character. " I, that am curtailed of this proportion, cheated of feature by dissembling nature, Deform'd, unfinish'd sent before my time Into this word scarce half made up"( 1.1.20-23) The first scene of the play begins with a soliloquy, which emphasizes Richard's physical isolation as he appears alone as he speaks to is audience. The idea of physical isolation is heightened by his references to his deformity such as "rudely stamped ....Cheated of feature by dissembling Nature, deformed unfinished". "( 1.1.21-22). This deformity would be an outward indication to his audience of the disharmony from Nature and viciousness of his spirit. As he hated "the idle pleasure of these days" and speaks of his plots to sent one brother against another, Richard seems socially apart from the figures around him, and perhaps regarded as an outsider or ostracized because of his deformity. His separation his family is emphasized when he says "Dive, thoughts down to my soul"(1.1.41) when he sees his brother approaching. He is unable to share his thought with his own family as he is plotting against them. Thus, we are given hints of his physical, social and spiritual isolation which is developed throughout the play. But despite these hints, he still refers to himself as part of the House of York, shown in the repeated use of "Our" The task which Shakespeare undertook was to mold the hateful constitution of Richard's Moral; character. Richard had to contend with the prejudices arising from his bodily deformity which was considered an indication of the depravity and wickedness of his nature. Richard's ambitious nature, his elastic intellect, and his want of faith in goodness conspire to produce his tendency to despise and degrade every surrounding being and object, even as his own person. He is never sincere except when he is about to commit a murder. "therefore, since I can not prove a lover, To entertain these fair well spoken days, I am determined to be a villain".As a villain Richard must be heartless, he can not let his emotions interfere with his actions.
Monday, January 13, 2020
Historical Development in the Field of Toxicology
Historical Development in the Field of Toxicology And Mechanisms and Factors Responsible for the Entrance of Toxicants in the Human body and their Harmful Effects Jorge D. Rebolledo Columbia Southern University Abstract The purpose of this paper is to make a short historical reference in the field of Toxicology and how this area of science has develop starting from centuries ago until our present. It is also the intention of this paper to explain how the toxics enter our body, how they are absorbed and the mechanisms responsible for that. Introduction As stated by E. Monosson, some define Toxicology as the study of toxic materials, including the clinical, industrial, economic, and legal problems associated with them. Although toxicologyâ€â€as a formally recognized scientific disciplineâ€â€is relatively new (with major developments in the mid-1900s), the science itself is thousands of years old. Consider the potential results of early trial and error experiences of hunter-gatherers for whom identifying a toxic plant or animal was a life or death situation. Some of the most poisonous substances known today are naturally produced chemicals including ricin from castor beans or tetrodotoxin from the puffer fish. Early humankinds’ careful observations of such plants or animals with toxic characteristics as frogs, containing curare, were put to use not only for avoidance of toxic substances but for weaponry as well. Many naturally-derived poisons were likely used for hunting, as medicinal (the Egyptians were aware of many such toxic substances as lead, opium and hemlock as early as 1500 BCE). Use extended eventually to political poisonings as practiced, for example, by the early Greeks and Romans. With time, poisons became widely used and with great sophistication. Notable poisoning victims include Socrates, Cleopatra, and Claudius. One of the more interesting stories resulting from a combination of both ancient history and current toxicological research, is the story of King Mithridates, king of Pontus (120-63 BC) who according to toxicology legend was so afraid that he might be a casualty of political poisoning, is said to have concocted a potion from a great number of herbs for his own consumption. It is believed he understood that by consuming small amounts of potential poisons, he might protect himself from any would-be poisoner. That is, he believed in the effectiveness of hormesis. Apparently, his plans worked so well that he gained a name for himself as one so mighty he could not be killed. Unfortunately, it is said that when circumstances were such that he desired to kill himself, he was unable to do so by ingesting poison and had to be run through by a sword instead. Whether or not the story is true, it has led current day scientists to speculate upon the ingredients of his potion. It is believed that some herbs that he may have used, for example, St. Johns Wort could truly have contributed to detoxification of some other poisons. Recent studies have demonstrated that St. Johns Wort (often used as an herbal remedy) can increase the metabolism or breakdown of certain drugs and chemicals. This early story of toxicology relates a very important conceptâ€â€that all animals have some kind of intrinsic ability for detoxifying a number of naturally-occurring toxicants in small doses (so that, in some cases low doses of chemicals may pass through the body without causing harm. From this we derive the concept of a chemical threshold), and that these processes can be altered by exposure to other chemicals. The question remains as to how adept animals, including humans, are at detoxifying many of the newer industrial chemicals or mixtures of industrial or industrial and natural chemicals. Additionally, it is well known that in some cases, detoxification of chemicals can produce even more toxic compounds. Pre-Industrial Toxicology As declared by E. Monosson, as humans sought to better understand natural compounds that were both beneficial and harmful to them, there was very little if any clear understanding of the fundamental chemical nature of substances. That is, there was no connection between the ‘extract’ and ‘essence’ of a poisonous plant or animal and any one particular chemical that might cause toxicity. In fact, an awareness of chemistry in its modern form did not occur until around the mid to late 1600s. Paracelsus, a physician from the sixteenth century and one of the early â€Å"Fathers of Toxicology†believed that all matter was composed of three â€Å"primary bodies†(sulfur, salt, and mercury). Yet, Paracelsus also coined the now famous maxim of the newly emerging discipline of toxicology: â€Å"All substances are poisons, there is none which is not a poison. The right dose differentiates a poison from a remedy. †(Paracelsus, 1493-1541) This phrase and Paracelsus’ name are committed to memory by hundreds of new toxicology students each year and has become the ‘motto’ of toxicology. Interestingly, if one takes Paracelsus at face value, it appears that in this quote he was referring to substances which served as potential remedies but could be poisonous if taken in high enough concentrations. Most of us are aware of the fact that overdosing can turn remedies to poisons, even with such apparently innocuous drugs as aspirin and Tylenol. Another branch on the toxicology family tree that developed in the sixteenth century, along with the study of drugs and the use of chemicals in hunting and warfare, was occupational toxicology. As humans learned how to remove and exploit such materials as coal, and metals and other minerals, occupational exposures to these chemical substances (and chemicals produced incidentally) resulted. Scientists eventually recognized the linkages among illnesses and exposures to these compounds. Some of the first reports of occupational illness, or diseases caused by activities related to specific occupations, can be found in literature from the mid- to late-1500s. Early occupational observations include the ill effects from lead mining and madness caused by mercury exposure (for example, the saying â€Å"mad as a hatter†was attributed to the common use of mercury in the hat felting process). Later, in the 1700s, Bernardino Ramazzini is credited with bringing to light diseases of tradesmen, including silicosis in stone workers and lead poisoning. In the late 1700s, Sir Percival Potts made one of the more famous observations in toxicology, linking an occupational exposure (in this case soot in chimney sweeps) to cancer of the scrotum. At this point we have discussed the pre-Industrial Revolution developments in toxicology, that were primarily devoted to the study of such naturally-occurring toxicants as the polyaromatic compounds contained in soot and heavy metals, and such toxins as botulinum toxin produced by the bacterium Clostridium botulinum. Toxicology and the Chemical and Industrial Revolution The chemical/Industrial Revolution of the mid-19th century released many naturally-occurring chemicals into the environment in unprecedented amounts. Also, it produced and released new substances unlike any that had existed in the natural world. With the production and use of these chemicals, and the need to protect humans from the toxic effects of industrial chemicals, toxicology eventually evolved to include its modern day branches: pharmacology, pesticide toxicology, general toxicology, and occupational toxicology. Towards the mid-late 20th century, environmental toxicology was developed to specifically address the effects on both humans and wildlife of chemicals released into the environment. A notable difference among the branches of toxicology is that pharmacology, pesticides and even occupational toxicology primarily have focused on the effects of relatively high concentrations of single chemicals. This compares to the relatively low concentrations of several different chemicals or chemical mixtures that are relevant to environmental toxicology. The chemicals considered by the earlier branches of toxicology were, and are, a known quantity. That is, the research was designed to address questions about specific, well-characterized chemicals, exposure conditions, and even concentration ranges rather than complex chemical mixtures. For example, pharmacologists might work with a particular active ingredient (e. g. , salicylic acid or aspirin), and be confident about the route of exposure (oral) and the concentration or dose. This is seldom the case in environmental toxicology, and hazardous waste assessment and cleanup in particular, where chemicals often are present in mixtures, routes of exposure may vary (for example, from oral to dermal to inhalation). Significantly, exposure concentrations prove difficult to determine. Mechanisms and Factors Responsible for the Entrance of Toxicants in the Human body and their Harmful Effects Absorption of toxicants Absorption is the process whereby toxicants gain entrance to the body. Ingested and inhaled materials, nonetheless, are considered outside the body until they cross the cellular barriers of the gastrointestinal tract or the respiratory system. To exert an effect on internal organs a toxicant must be absorbed, although such local toxicity as irritation, may occur. Absorption varies greatly with specific chemicals and with the route of exposure. For skin, oral or respiratory exposure, the exposure dose (or, â€Å"outside†dose) is usually only a fraction of the absorbed dose (that is, the internal dose). For substances injected or implanted directly into the body, exposure dose is the same as the absorbed or internal dose. Several factors affect the likelihood that a foreign chemical or, xenobiotic, will be absorbed. According to E. Monosson, the most important are: †¢ Route of exposure Concentration of the substance at the site of contact †¢ Chemical and physical properties of the substance The relative roles of concentration and properties of the substance vary with the route of exposure. In some cases, a high percentage of a substance may not be absorbed from one route whereas a low amount may be absorbed via another route. For example, very little DDT powder will penetrate the skin whereas a high percentage will be absorbed when it is swallowed. Due to such route-specific differences in absorption, xenobiotics are often ranked for hazard in accordance with the route of exposure. A substance may be categorized as relatively non-toxic by one route and highly toxic via another route. The primary routes of exposure by which xenobiotics can gain entry into the body are: †¢ Gastrointestinal tract: Key in environmental exposure to food and water contaminants and is the most important route for many pharmaceuticals. †¢ Respiratory tract: Key in environmental and occupational exposure to aerial toxicants and some drugs that use this route (i. e. : inhalers). †¢ Skin: Also an environmental and occupational exposure route. A lot of medicines are applied to the skin directly. Other routes of exposureâ€â€used primarily for specific medical purposesâ€â€are: †¢ Injections (IV, Subcutaneous, Intradermal, Intrathecal) basically used for medications. †¢ Implants (Hormone patches) †¢ Conjunctival instillations (Eye drops) †¢ Suppositories For a toxic to enter the body (as well as move within, and leave the body) it must pass across cell membranes (cell walls). Cell membranes are formidable barriers and major body defenses that prevent foreign invaders or substances from gaining entry into body tissues. Normally, cells in solid tissues (for example, skin or mucous membranes of the lung or intestine) are so tightly compacted that substances cannot pass between them. Entry, therefore, requires that the xenobiotic have some capability to penetrate cell membranes. Also, the substance must cross several membranes in order to go from one area of the body to another. In essence, for a substance to move through one cell requires that it first move across the cell membrane into the cell, pass across the cell, and then cross the cell membrane again in order to leave the cell. This is true whether the cells are in the skin, the lining of a blood vessel, or an internal organ (for example, the liver). In many cases, in order for a substance to reach its site of toxic action, it must pass through several membrane barriers. Cell membranes surround all body cells and are basically similar in structure. They consist of two layers of phospholipid molecules arranged like a â€Å"sandwich†and also known as â€Å"phospholipid bilayer†. Each phospholipid molecule consists of a phosphate head and a lipid tail. The phosphate head is polar so it is hydrophilic (attracted to water). In contrast, the lipid tail is lipophilic (attracted to lipid-soluble substances). The two phospholipid layers are oriented on opposing sides of the membrane so that they are approximate mirror images of each other. The polar heads face outward and the lipid tails inward. The cell membrane is tightly packed with these phospholipid moleculesâ€â€interspersed with various proteins and cholesterol molecules. Some proteins span across the entire membrane providing for the formation of aqueous channels or pores. Some toxicants move across a membrane barrier with relative ease while others find it difficult or impossible. Those that can cross the membrane, do so by one of two general methods: either passive transfer or facilitated transport. Passive transfer consists of simple diffusion (or osmotic filtration) and is â€Å"passive†in that there is no requirement for cellular energy or assistance. Some toxicants cannot simply diffuse across the membrane. They require assistance that is facilitated by specialized transport mechanisms. The primary types of specialized transport mechanisms are: †¢ Facilitated diffusion †¢ Active transport †¢ Endocytosis (phagocytosis and pinocytosis). Passive transfer is the most common way that xenobiotics cross cell membranes. Two factors determine the rate of passive transfer: †¢ Differences in concentrations of the substance on opposite sides of the membrane (substance moves from a region of high concentration to one having a lower concentration. Diffusion will continue until the concentration is equal on both sides of the membrane); and †¢ Ability of the substance to move either through the small pores in the membrane or through the lipophilic interior of the membrane. Properties of the chemical substance that affect its ability for passive transfer are: †¢ Lipid solubility Molecular size †¢ Degree of ionization (that is, the electrical charge of an atom) Substances with high lipid solubility readily diffuse through the phospholipid membrane. Small water-soluble molecules can pass across a membrane through the aqueous pores, along with normal intracellular water flow. Large water-soluble molecules usually cannot make it through the small pores, although some may diffuse through the l ipid portion of the membrane, but at a slow rate. In general, highly ionized chemicals have low lipid solubility and pass with difficulty through the lipid membrane. Most aqueous pores are about 4 angstrom (A) in size and allow chemicals of molecular weight 100-200 to pass through. Exceptions are membranes of capillaries and kidney glomeruli that have relatively large pores (about 40A) that allow molecules up to a molecular weight of about 50,000 (molecules slightly smaller than albumen which has a molecular weight of 60,000) to pass through. Facilitated diffusion is similar to simple diffusion in that it does not require energy and follows a concentration gradient. The difference is that it is a carrier-mediated transport mechanism. The results are similar to passive transport but faster and capable of moving larger molecules that have difficulty diffusing through the membrane without a carrier. Examples are the transport of sugar and amino acids into red blood cells (RBCs), and into the central nervous system (CNS). Some substances are unable to move with diffusion, unable to dissolve in the lipid layer, and are too large to pass through the aqueous channels. For some of these substances, active transport processes exist in which movement through the membrane may be against the concentration gradient: they move from low to higher concentrations. Cellular energy from adenosine triphosphate (ADP) is required in order to accomplish this. The transported substance can move from one side of the membrane to the other side by this energy process. Active transport is important in the transport of xenobiotics into the liver, kidney, and central nervous system and for maintenance of electrolyte and nutrient balance. Many large molecules and particles cannot enter cells via passive or active mechanisms. However, some may enter, by a process known as endocytosis. In endocytosis, the cell surrounds the substance with a section of its cell wall. This engulfed substance and section of membrane then separates from the membrane and moves into the interior of the cell. The two main forms of endocytosis are phagocytosis and pinocytosis. In phagocytosis (cell eating), large particles suspended in the extracellular fluid are engulfed and either transported into cells or are destroyed within the cell. This is a very important process for lung phagocytes and certain liver and spleen cells. Pinocytosis (cell drinking) is a similar process but involves the engulfing of liquids or very small particles that are in suspension within the extracellular fluid. Gastrointestinal Tract The gastrointestinal tract (GI tract, the major portion of the alimentary canal) can be viewed as a tube going through the body. Its contents are considered exterior to the body until absorbed. Salivary glands, the liver, and the pancreas are considered accessory glands of the GI tract as they have ducts entering the GI tract and secrete enzymes and other substances. For foreign substances to enter the body, they must pass through the gastrointestinal mucosa, crossing several membranes before entering the blood stream. Substances must be absorbed from the gastrointestinal tract in order to exert a systemic toxic effect, although local gastrointestinal damage may occur. Absorption can occur at any place along the entire gastrointestinal tract. However, the degree of absorption is strongly site dependent. Three main factors affect absorption within the various sites of the gastrointestinal tract: †¢ Type of cells at the specific site †¢ Period of time that the substance remains at the site †¢ pH of stomach or intestinal contents at the site. Under normal conditions, xenobiotics are poorly absorbed within the mouth and esophagus, due mainly to the very short time that a substance resides within these portions of the gastrointestinal tract. There are some notable exceptions. For example, nicotine readily penetrates the mouth mucosa. Also, nitroglycerin is placed under the tongue (sublingual) for immediate absorption and treatment of heart conditions. The sublingual mucosa under the tongue and in some other areas of the mouth is thin and highly vascularized so that some substances will be rapidly absorbed. The stomach, having high acidity (pH 1-3), is a significant site for absorption of weak organic acids, which exist in a diffusible, nonionized and lipid-soluble form. In contrast, weak bases will be highly ionized and therefore are absorbed poorly. Chemically, the acidic stomach may break down some substances. For this reason those substances must be administered in gelatin capsules or coated tablets, that can pass through the acidic stomach into the intestine before they dissolve and release their contents. Another determinant that affects the amount of a substance that will be absorbed in the stomach is the presence of food. Food ingested at the same time as the xenobiotic may result in a considerable difference in absorption of the xenobiotic. For example, the LD50 for Dimethline (a respiratory stimulant) in rats is 30 mg/kg (or 30 parts per million) when ingested along with food, but only 12 mg/kg when it is administered to fasting rats. The greatest absorption of chemicals, as with nutrients, takes place in the intestine, particularly in the small intestine (see Figure 9). The intestine has a large surface area consisting of outward projections of the thin (one-cell thick) mucosa into the lumen of the intestine (the villi). This large surface area facilitates diffusion of substances across the cell membranes of the intestinal mucosa. Since the intestinal pH is near neutral (pH 5-8), both weak bases and weak acids are nonionized and are usually readily absorbed by passive diffusion. Lipid soluble, small molecules effectively enter the body from the intestine by passive diffusion. In addition to passive diffusion, facilitated and active transport mechanisms exist to move certain substances across the intestinal cells into the body, including such essential nutrients as glucose, amino acids and calcium. Also, strong acids, strong bases, large molecules, and metals (and some important toxins) are transported by these mechanisms. For example, lead, thallium, and paraquat (herbicide) are toxicants that are transported across the intestinal wall by active transport systems. The high degree of absorption of ingested xenobiotics is also due to the slow movement of substances through the intestinal tract. This slow passage increases the length of time that a compound is available for absorption at the intestinal membrane barrier. Intestinal microflora and gastrointestinal enzymes can affect the toxicity of ingested substances. Some ingested substances may be only poorly absorbed but they may be biotransformed within the gastrointestinal tract. In some cases, their biotransformed products may be absorbed and be more toxic than the ingested substance. An important example is the formation of carcinogenic nitrosamines from non-carcinogenic amines by intestinal flora. Very little absorption takes place in the colon and rectum. As a general rule, if a xenobiotic has not been absorbed after passing through the stomach or small intestine, very little further absorption will occur. However, there are some exceptions, as some medicines may be administered as rectal suppositories with significant absorption. An example, is Anusol (hydrocortisone preparation) used for treatment of local inflammation which is partially absorbed (about 25%). Respiratory Tract Many environmental and occupational agents as well as some pharmaceuticals are inhaled and enter the respiratory tract. Absorption can occur at any place within the upper respiratory tract. However, the amount of a particular xenobiotic that can be absorbed at a specific location is highly dependent upon its physical form and solubility. There are three basic regions to the respiratory tract: †¢ Nasopharyngeal region †¢ Tracheobronchial region †¢ Pulmonary region By far the most important site for absorption is the pulmonary region consisting of the very small airways (bronchioles) and the alveolar sacs of the lung. The alveolar region has a very large surface area (about 50 times that of the skin). In addition, the alveoli consist of only a single layer of cells with very thin membranes that separate the inhaled air from the blood stream. Oxygen, carbon dioxide and other gases pass readily through this membrane. In contrast to absorption via the gastrointestinal tract or through the skin, gases and particles, which are water-soluble (and thus blood soluble), will be absorbed more efficiently from the lung alveoli. Water-soluble gases and liquid aerosols can pass through the alveolar cell membrane by simple passive diffusion. In addition to solubility, the ability to be absorbed is highly dependent on the physical form of the agent (that is, whether the agent is a gas/vapor or a particle). The physical form determines penetration into the deep lung. A gas or vapor can be inhaled deep into the lung and if it has high solubility in the blood, it is almost completely absorbed in one respiration. Absorption through the alveolar membrane is by passive diffusion, following the concentration gradient. As the agent dissolves in the circulating blood, it is taken away so that the amount that is absorbed and enters the body may be quite large. The only way to increase the amount absorbed is to increase the rate and depth of breathing. This is known as ventilation-limitation. For blood-soluble gases, equilibrium between the concentration of the agent in the inhaled air and that in the blood is difficult to achieve. Inhaled gases or vapors, which have poor solubility in the blood, have quite limited capacity for absorption. The reason for this is that the blood can become quickly saturated. Once saturated, blood will not be able to accept the gas and it will remain in the inhaled air and then exhaled. The only way to increase absorption would be to increase the rate of blood supply to the lung. This is known as flow-limitation. Equilibrium between blood and the air is reached more quickly for relatively insoluble gases than for soluble gases. The absorption of airborne particles is usually quite different from that of gases or vapors. The absorption of solid particles, regardless of solubility, is dependent upon particle size. Large particles (>5  µM) are generally deposited in the nasopharyngeal region ((head airways region) with little absorption. Particles 2-5  µM can penetrate into the tracheobronchial region. Very small particles (
Sunday, January 5, 2020
The Wonders Of Modern Science And Astronomy - 1581 Words
This work is a celebration of the wonders of modern science and astronomy. I set out to make a children s book that would be fun and educational in order to further younger generation s interest in fields of science. The work of scientists makes a huge difference in everybody s life regardless if you become one or not.Science makes the future come to us, they bring us to the farthest spots in time and space and teach us a process for establishing a truth and making wise decisions. I wanted a book that makes people slow down, think a little more, and dream, even if it is only for a moment.What is laid out here is the process of developing this book s visuals and the research that heavily influenced them. We are a species that are innately nomads. We strive to find that new green pasture that is just over the hill we have not passed yet. In current times we have explored all frontiers available on earth, but now we have a great opportunity to search deep into space. Deep Space explor ation is in the efforts to help give us a perspective on our place in the cosmos, inspire, and help our civilization persist through time. Despite this we are constrained to how far we can travel in theory, no longer can we travel unending distances. We are constrained to a cluster of 54 Galaxies that are drifting away from other clusters. The nearest candidate to be a life hosting star is orbiting Proxima Centauri, which is 4.2 Light Years from our solar system and ourShow MoreRelatedScience Throughout the Ages912 Words  | 4 PagesThe term Science comes from the Latin word scientia, meaning knowledge. The definition of science is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. An older term of science refers to a body of knowledge itself, of anything that can be successfully applied to a situation. Someone who practices science is known as a scientist. 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The modern day scientists of this era began to criticize the Aristotelian and Medieval Cosmological views of the world as a result of further experimentation. Furthermore, the Copernican heliocentric model of the universe created an uproar a mong scientists and theologians alike. Most scientists were loyal to Aristotle’s cosmos and were unwilling to accept the new world view, whileRead MoreEgyptian Contributions And Greek Culture1678 Words  | 7 Pagescivilization is the basis of philosophy, science, and medicine that is often times solely credited to the Greeks. PURPOSE STATEMENT After thorough research and analysis the Nile Valley Contributions to Greek civilization are evident. THE BEGINNINGS Ancient Greece is regarded as the beginnings of advanced sciences and philosophies and the fundamentals of the western world. For years, Greek culture has been taught in schools and held in a high esteem. 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Both civilizations also introduced a wider variety of religion, mathematics, science, art and architecture concepts, machinery, military technology and strategy, astronomy, agriculture, philosophy, education, literature, politics, and much more that everyone cling onto throughout a day-to-dayRead MoreThe Discovery Of Space Exploration1560 Words  | 7 Pagesthat the prospects of discovering an alien organism or a second Earth are exciting. And we keep getting closer. History is flooded with major astronomical discovery. Of course, this had not been without controversy (as Galileo knew all too well). The modern controversy regarding space exploration is not of religious concern, however, but a socioeconomic one. Before writing this article, I had my own reservations about space exploration. Why not focus our resources on exploring and improving our ownRead MoreJohn Dalton s Atomic Theory1360 Words  | 6 PagesJohn Dalton Lived 1766 – 1844. John Dalton’s Atomic Theory laid the foundations of modern chemistry. John Dalton’s Early Life and Education John Dalton was born on September 6, 1766, in Eaglesfield, England. His father was a weaver, who owned a house and a small amount of land. Both of his parents were Quakers. Although Quakers were Christians, they were seen as dissenters by the established Church of England. As a result of this, John Dalton’s higher educational opportunities were restrictedRead MoreAlexander The Great s Large Accomplishments1528 Words  | 7 PagesAlexander the Great’s large accomplishments in the third century BC changed the landscape of Afro-Eurasia in ancient times, and arguably through modern day. With the growth of his empire came the spread of Hellenistic culture throughout the lands he conquered. From the Mediterranean to Asia to the Middle East he helped expand trade routes and most of all the spread of ideas in religion, politics, and culture. One of the larger aspects of this spread of culture from Alexander was the expansion ofRead MoreAncient Aliens Essay examples1235 Words  | 5 Pagesin the scientific community. Ancient alien theorists, like Erich von Daniken and Zecharia Sitchin, believe that extraterrestrials came to earth thousands of years ago. Some hypothesize that ancient aliens are responsible for ancient technological wonders, and that they helped to shape human civilization. Furthermore, the belief that ancient gods were in fact aliens, misinterpreted as gods by the ancient people. As it turns out, there is quite a bit of evidence to support some of these ancient alien
Friday, December 27, 2019
Evaluating the use of e commerce in a brick and click organization that balances ecommerce with a continued high street presence Free Essay Example, 2500 words
The success of the company may also be attributable to strong leadership and innovation (De Toni and Tonchia, 2003, p. 950). One of the most notable developments by Tesco happened in 2000 when Tesco. com was launched. In 2001, the Chief Executive of the Tesco acknowledged that e-commerce is a major development to the company which helped change the relationship between the company and its customers. Tesco. com is among the best online shopping systems globally as the website is able to take more than 70, 000 orders weekly. The websites helped change the purchasing behaviors of customers as they do not have to physically get to the stores to buy their groceries. The website essentially offers customers the benefit of shopping from the convenience of their homes and to have their products delivered there (Palmer, 2004, p. 1075). When ordering online, customers can have their products delivered the next day or they can even order 28 days prior to the delivery. Tesco has further developed an online system to allow customers to make purchase from their Smart-phones. This is a form of e-commerce known referred as the mobile commerce (m-commerce) and was necessitated by the fact that more customers can access internet from their mobile phones in contrast to using computers which are less portable (Palmer, 2004, p. We will write a custom essay sample on Evaluating the use of e commerce in a brick and click organization that balances ecommerce with a continued high street presence or any topic specifically for you Only $17.96 $11.86/pageorder now 1080). Additionally, the company has a system to maintain customer loyalty and therefore it introduced Tesco Loyalty Club. This strategy was introduced to ensure that the company is able to lock in customers to prevent them from being taken by its competitors as they earn points for every purchase which they can later redeem for some products from the store (Drejer, 2000, p. 207). Tesco does not only rely on technology to sell its products but it also relies on computer based technologies to manage it supply chain system. The company initiated an ambitious program that saw the company computerize the supply chain (Drejer, 2000, p. 206). The company set up centralized warehouses where supplies could be held for dispatcher to the stores rather than relying on the manufacturers to deliver product to the stores directly as this can cause inconveniences. In spite of Tesco being a leader in use of e-commerce, it has maintained high street presence where a significant number of its customers are able to buy directly from its store therefore becoming a good example of a brick and click organization that has maintained a balance between use of e-commerce and street presence (Drejer, 2000, p.
Thursday, December 19, 2019
Do You Have A Love For Sports - 1130 Words
Do you have a love for sports? Well I love sports and my job won’t even feel like work because of how much i m around sports. This career I have chose is to be a coach.I have took career cluster surveys and my top career cluster is Education and training. As a coach I will get to teach ametuer up to professional athletes skills to improve them in their sport. I will also get to instruct my team during games and lead them to wins. I will enjoy knowing that I shaped my team into better men. More than enjoying the wins my team gets. I chose this career because of my love for sports. I love football so much that i want to go pro in it. Coaching will be something to fall back on after that. In fact, It won’t even feel like i’m doing anything because I enjoy doing something I have enjoyed to do since a kid. I feel that coaching is the very best career based on the topics I researched. These topics include work environment, education and training, important qualities, a nd salary as well as job outlook. Work Environment Coaches have to know what is going on during a game. Coaches need to know when to sub players so they don’t get tired during a game. As an athlete I know that rest is a great thing for the player. If the player is tired he/she won’t be playing to their full potential. They also need to call the proper plays. I know that a coach calling the right plays can lead to a win for the team and the coach will have to recognize the other team’s formation in order to callShow MoreRelatedWhat Does Sports Fan Stand For?891 Words  | 4 PagesEveryday there are competitions in sports going on. Thousands of people gathered around to watch that one sport they truly love. Those people are called â€Å"sports fan†. What does sports fan stand for? According to Oxford English Dictionary the word â€Å"fan†means â€Å"A fanatic; in modern English (orig. U.S.): a keen and regular spectator of a (professional) sport, orig. of baseball; a regular supporter of a (profe ssional) sports team; hence, a keen follower of a specified hobby or amusement, and gen. anRead MoreDefining Happiness Is Hard For Some People846 Words  | 4 Pagesalready have. This means that happiness is not something materialistic, but is instead found through intrinsic motivation. Despite its definition online or in the dictionary, each person has their own definition of happiness, including myself. In my opinion, there are three simple, key things to make you happy: love, doing what you love, and finding happiness within oneself. True happiness comes from enjoying the things one has and taking advantage of the people who love and support you. A quoteRead MoreMy Favorite Sport744 Words  | 3 PagesWrestling is one of the top ten most dangerous sports, even though it is I still love it. Wrestling is a tough sport because anything can happen from it. The common injuries you can get from wrestling are an ankle sprain, wrist sprain, overtraining syndrome, muscle soreness, a fractured finger, and dehydration. Some of the serious injuries are concussion, neck sprain, shoulder sprain and shoulder dislocation, and a torn anterior cruciate ligament. You can even tear all four cruciate ligaments in yourRead MoreHow Softball Is My Favorite Sport1409 Words  | 6 Pageslauren kazanjian English 1 Level 2: blue expository essay 10 October 2015 Swing, hit, homerun! Softball is my favorite sport. I love the excitement it brings me every time i smack the ball out of the park. The game of softball was created on Thanksgiving day 1887, but did not become a NCAA approved sport until 1910. (http://www.athleticscholarships.net/history-of-softball.htm) One person that i look up to as a role model is Jennie Finch. She is one of the best softball players that hasRead MoreMy Family Essay1545 Words  | 7 Pagesof family and the values attached to it have helped shape my life in many ways. I am very close with who I consider my family and the meaning of this could differ from person to person. To me, family consists of people who you love, trust and care for. I also consider some of my friends and teammates in this category as well. Family and friends, sports, and my health are the main components of my life. These subcultures have helped define my life and have shaped me into the person I am today.   Read MoreFootball: Good or Bad? â€Å"Is it ok to watch football†An article by Ian Crouch demonstrates how1100 Words  | 5 Pagesâ€Å"Is it ok to watch football†An article by Ian Crouch demonstrates how dangerous the sport is to its player’s bodies and brains. Sports are in our everyday lives, but do we really play the sport for excitement or for violence? Football is a sport that is simply full of danger and threat all the time. That’s just sports; there will always be risk for injury with any sport played. When fans watch football they love to see the big hit or the game winning touchdown play to wide-receivers. Violence raisesRead MorePersuasive Essay On Pride In Sports1528 Words  | 7 PagesPride in Sports Being told to â€Å"take pride in what you do†is a phrase common in the athletic world. From work, to sports, or even just doing your school work, elders always tell us younger generations to â€Å"take pride in what you do†. Taking pride to what they do as an athlete is something coaches, and parents pound in athletes’ heads every day. But, what is pride? How do inexperienced athletes have pride in something when nobody tells these athletes how to fulfill this this aspect of â€Å"pride†? NameRead MoreSexism in Sports Essay1257 Words  | 6 Pagesdifferent work environments for quite some time. It especially raises big conversation, and an ongoing problem in the sports industry. Not only does it affect the women who work in the industry, but also homosexuals, and minorities. For so long sexism has been a topic of discussion, but no real attempts at change have been made. If there was more protection for woman and players who work in sports, it could help to get women more involved in the field, establish rules that will protect people from sexismRead MoreIs Playing A Sport?1619 Words  | 7 PagesPlaying a sport is tough enough as it is, tasks such as training, potential for injuries, mental preparation and making sure the team reaches their full potential are all factors. Now, imagine not feeling like a part of that team due to the person you want to love. I was fortunate enough to be able to have a first-hand look into what being a gay athlete is like. My ex-t eammate and friend Ryan Houchen, great athlete, even better person. Ryan himself is a homosexual athlete, he played hockey for MetroRead MoreSport Manager Interview941 Words  | 4 PagesSport Manager Interview Paper For my Sport Manager Interview I interviewed Mr. Matt Seibring who is an Assistant Director in Competitive Sports. I asked Mr. Matt questions that related to his job and basically to help prepare and give me advice for my career plans in the future. In the Assistant Directory role they have professional staff that reports all information and how everything is going throughout the work day. Mr. Matt manages the coordinators and has to make sure all of the supervisors
Wednesday, December 11, 2019
Electrophoresis Essay Research Paper I Purpose perform free essay sample
Electrophoresis Essay, Research Paper I. Aim ? perform cataphoresis utilizing limitation enzymes and lambda Deoxyribonucleic acid ? understand how a limitation enzyme plants ? analyse a exposure of cataphoresis ? understand how gel cataphoresis offprints DNA molecules in a mixture ? how to utilize cataphoresis to divide Deoxyribonucleic acid fragments ? find unknown DNA fragment sizes when given DNA fragments of known size II. Materials agarose pulverization projecting tray and comb camera crushed ice container distilled H2O Deoxyribonucleic acid samples electronic graduated table with tare cataphoresis box 250 milliliters Erlenmeyer flasks movie graduated cylinder goon ice lading dye microcentrifuge micropipet and tips 1.5 ml reaction tubings and racks limitation buffer limitation enzymes ( HindIII, EcoRI, BamHI ) 10x TEA buffer UV filter UV transilluminator 37? C H2O bath weighing boat III. Procedure Topographic point the weighing boat on the graduated table and tare. Weigh out 0.8 milliliter of agarose pulverization and topographic point it into a 250 milliliter Erlenmeyer flask. Add 10 milliliter of 10x TEA buffer and 90 milliliter of distilled H2O into a calibrated cylinder to make a 1x TEA buffer solution. Add this to the Erlenmeyer flask incorporating the 0.8 milliliter of agarose. Dissolve and boil the agarose solution in a microwave, about 2-3 proceedingss. Topographic point clean underside of the casting tray in topographic point, and pour in the agarose solution. Put the casting comb in topographic point. Allow gel mold to put undisturbed until about opaque, about 10 proceedingss. Fill a calibrated cylinder with 50 milliliters of 10x TEA buffer and 450 milliliter of distilled H2O, making 500 milliliter of 1x TEA buffer. In each of the four limitation enzyme tubings, combine 1.0? cubic decimeter of limitation buffer, 7.0? cubic decimeter of distilled H2O, 1.0? cubic decimeter of the specific enzyme ( either HindIII, EcoRI, or BamHI ) . For the control, add no enzyme. Close the caps tightly and put them equally balanced in the microcentrifuge and spin for 2-3 seconds. Put the tubings in the 37? C H2O bath. When the gel has solidified remover the comb in a careful straight up gesture. Remove the glass home base underside without upseting the gel and topographic point it in the cataphoresis box with the Wellss towards the cathode terminal. Pour the prepared 1X TEA buffer carefully over the gel until the liquid degree wholly covers the gel and is approximately 1 or 2 millimeters above the surface of the gel. Add 2? cubic decimeter of lading dye to each of the enzyme tubes utilizing the micropipet and whirl them in the extractor. Extract 10? cubic decimeter of the first sample and burden it into the first good. Repeat this with the other samples, altering tips between each. Attach the power supply to the cataphoresis box. Put it to 100 Vs and 40 milliamps and trip it. After about 45 proceedingss or until the dye is about? of the down, turn off the power supply and unplug the box. Using baseball mitts, take the gels from the box and put them on the transilluminator. The teacher will transport out the picture taking of the cataphoresis gel. Clean the lab country. IV. Observations and Consequences HindIII EcoRI BamHI Control Distance Act. BP Distance Cal. BP Distance Cal. BP Distance Cal. BP 3.4 centimeter 25,000* 3.5 centimeter 23,000 3.8 centimeter 19,000 3.7 centimeter 20,000 4.8 9,416 5.3 7,800 4.2 15,000 # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; 5.9 6,557 6.4 5,200 5.7 6,800 # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; 6.7 4,361 7.1 4,000 5.9 6,500 # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; 11.3 2,322 8.7 3,300 6.7 4,300 # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; 12.1 2,027 # 8212 ; # 8212 ; # 8212 ; # 8211 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; # 8212 ; * = rounded base brace All deliberate base brace ( Cal. BP ) are rounded figures. V. Decisions Electrophoresis literally means # 8220 ; to transport with electricity. # 8221 ; It is the usage of limitation enzymes and electrical current to mensurate sections of Deoxyribonucleic acid from a sample. Restriction enzymes are enzymes found in bacteriums. These are enzymes that are able to cut through the phosphate-sugar anchor of DNA at limitation sites. Restriction sites are certain base sequences recognized by these enzymes. In bacteriums, limitation enzymes act as a defence against occupying viruses. When the viral DNA is release into the cell, the limitation enzymes cut it into pieces, rendering it useless and unable to move upon the cell. Any other bacteriums come ining the cell will besides be cut if it contains the base sequence recognized by the enzyme. Every species of bacterium has at least one limitation enzyme. Restriction enzymes are used in familial technology to do complementary cuts that allow the interpolation of a familial codification into a genome. In cataphoresis, limitation enzymes cut at the limitation sites on the Deoxyribonucleic acid sample. It cuts every bit many times as the base sequence appears on the sample. After the sample is cut, buffers, dye, and a substance called ethidium bromide is added to the sample. It is so placed into the well of an agarose gel. An electrical current is run through this, and because DNA has a negative charge it is dragged through it towards the positive terminal. The Deoxyribonucleic acid weaves through the agarose gel, the smallest braces traveling the farthest merely because they are more manoeuvrable. The longer sections move more easy through the agarose. When the sample has run about? of the manner through the gel, the current is disconnected, halting the motion of the DNA. The gel is so placed on an ultraviolet transilluminator. Ethidium bromide is sensitive to UV beams, so it is seen under the transilluminator. A image is so taken and the distance and base braces can be measured and calculated. The buffer used in this is TEA buffer. It is made of Tris and EDTA. Tris keeps the pH invariable at about 8.0, and EDTA pulls out low degrees of Na ethanoate. Since cataphoresis basically measures the distance between limitation sites of a certain limitation enzyme, it is helpful in slaying and colza instances, where blood or seeds of the suspect is found as grounds. In the instance of colza, a limitation enzyme is added with the blood or seeds grounds. A blood sample is taken from the suspect and DNA is spooled from it. The same limitation enzyme is added to it, and both samples are run through cataphoresis. Since every individual individual has different familial stuff, a lucifer in sections between limitation sites would be an impossibleness to be classified pure happenstance. This would clearly place the suspect as the culprit. A difference in section lengths would unclutter the suspect, as the DNA would be clearly different. In our cataphoresis experiment, it is shown how 3 different limitation enzymes act wholly otherwise on the same sample of DNA. This is because each enzyme has a different limitation site it acts upon. The control in this experiment merely shows that Deoxyribonucleic acid without any cuts would run, but would run as a big bunch and would run really easy, as it can non steer easy through the gel matrix. VI. Questions 2. Restriction enzymes are enzymes that use DNA as a substrate. When the proper base sequence, called a limitation or acknowledgment site, is found the enzyme Acts of the Apostless by cutting between the anchor two specified bases. 3. Restriction enzymes are found of course in bacteriums. They act as a protection against viral infections, as they break down incoming viral DNA. 4. The electricity in cataphoresis Acts of the Apostless on DNA as a magnet does to another magnet. Deoxyribonucleic acid has a somewhat negative charge. The samples incorporating Deoxyribonucleic acid are loaded at the cathode or negative terminal. When the power is activated, the Deoxyribonucleic acid is attracted towards the positive terminal of the cataphoresis box. The agarose gel provides a agency of decelerating the DNA down. The Deoxyribonucleic acid fragments must work through the gel matrix in order to make the terminal. 5. 6. The loading Acts of the Apostless as a point of mention. It allows the individual executing the experiment to see how far down the Deoxyribonucleic acid sample has moved. The Deoxyribonucleic acid is photographed utilizing ethidium bromide, a UV-sensitive substance and an ultraviolet transilluminator to foreground the DNA strands.
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